Sermorelin
A GHRH (1–29) analog that stimulates the body's natural growth hormone production through normal pituitary feedback.
Overview
Sermorelin is a 29-amino-acid fragment of natural GHRH, retaining full biological activity. It has decades of clinical use behind it as a more physiologic alternative to direct HGH replacement, particularly in age-related GH decline protocols.
Benefits
- Stimulates natural GH release in pulsatile pattern
- Improves sleep depth
- Supports lean mass and recovery
- Considered safer than direct HGH due to feedback control
Mechanism of Action
Sermorelin acts on pituitary GHRH receptors to trigger endogenous GH pulses, preserving normal somatostatin feedback to prevent overproduction.
Dosage (informational only)
- Typical range
- 100–500 mcg per dose
- Frequency
- Nightly subcutaneous administration
Often dosed before bed to align with the natural overnight GH pulse.
Side Effects
- Injection site reactions
- Flushing or headache
- Transient water retention
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