Ipamorelin
A selective ghrelin receptor agonist that triggers clean, pulsatile GH release without significant cortisol or prolactin spikes.
Overview
Ipamorelin is a pentapeptide GHRP (growth hormone releasing peptide) known for its selectivity. Unlike older GHRPs, it produces a strong GH pulse without elevating cortisol, prolactin, or aldosterone meaningfully.
Benefits
- Boosts GH release without hormonal disruption
- Supports recovery and lean mass
- Often used to improve sleep quality
- Synergizes with GHRH analogs like CJC-1295
Mechanism of Action
Ipamorelin binds to ghrelin/GHS-R receptors in the pituitary and hypothalamus, mimicking ghrelin's GH-releasing action while sparing the appetite and cortisol pathways targeted by other GHRPs.
Dosage (informational only)
- Typical range
- 100–300 mcg per dose
- Frequency
- 1–3x daily, often pre-bed
Commonly stacked with CJC-1295. Empty stomach administration optimizes the GH pulse.
Side Effects
- Mild head rush or flushing
- Hunger (less than with other GHRPs)
- Injection site irritation
Related peptides
A non-peptide ghrelin mimetic taken orally to elevate GH and IGF-1 over a 24-hour window.
An FDA-approved stabilized GHRH analog used to reduce visceral fat, with broader interest in body composition and cognition research.
A GHRH (1–29) analog that stimulates the body's natural growth hormone production through normal pituitary feedback.