MK-677 (Ibutamoren)
A non-peptide ghrelin mimetic taken orally to elevate GH and IGF-1 over a 24-hour window.
Overview
MK-677, also called Ibutamoren, is a non-peptide ghrelin receptor agonist. Unlike injectable GHRPs, it offers a long-acting oral route, sustaining elevated GH and IGF-1 levels around the clock.
Benefits
- Sustained 24-hour GH and IGF-1 elevation
- Supports deeper sleep and faster recovery
- Increases appetite and lean tissue accumulation
- No injection required
Mechanism of Action
MK-677 mimics ghrelin at the GHS-R1a receptor, prompting the pituitary to release growth hormone in physiological pulses while increasing IGF-1 over time.
Dosage (informational only)
- Typical range
- 10–25 mg per day
- Frequency
- Once daily, typically at night
Effects on appetite, water retention, and insulin sensitivity should be monitored. Not for use in those with prediabetic patterns.
Side Effects
- Increased appetite
- Transient water retention
- Mild numbness or tingling
- Possible reduced insulin sensitivity with long-term use
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