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Weight Loss

Best peptides for weight loss.

Weight loss peptides — particularly GLP-1 and dual GLP-1/GIP agonists — work by regulating appetite, slowing gastric emptying, and improving insulin sensitivity. They have become some of the most studied compounds in modern metabolic medicine.

9 peptides in this category

Weight Loss
Semaglutide
Appetite regulation and metabolic control

A long-acting GLP-1 receptor agonist studied for its effects on appetite, satiety, and glucose regulation.

Weight Loss
Tirzepatide
Dual incretin therapy for weight and glucose control

A dual GIP and GLP-1 receptor agonist with strong effects on appetite, glucose handling, and body composition.

Weight Loss
Retatrutide
Triple-agonist next-generation weight loss

An investigational triple agonist of GLP-1, GIP, and glucagon receptors producing some of the largest weight-loss results recorded in trials.

Weight Loss
Orforglipron
Oral GLP-1 agonist for weight loss

A small-molecule oral GLP-1 receptor agonist studied as a needle-free alternative to injectable incretin therapy.

Weight Loss
AOD-9604
Lipolytic HGH fragment for fat loss

A modified C-terminal fragment of human growth hormone designed for fat-loss effects without the broader anabolic action of full HGH.

Weight Loss
Cagrilintide
Long-acting amylin analog for weight loss

A long-acting amylin analog developed to be combined with semaglutide for enhanced weight loss (CagriSema).

Weight Loss
Mazdutide
Dual GLP-1 / glucagon receptor agonist

A dual GLP-1 / glucagon receptor agonist developed by Innovent and Eli Lilly for type 2 diabetes and weight loss.

Weight Loss
Survodutide
Dual GLP-1 / glucagon agonist for obesity and MASH

A weekly dual GLP-1 / glucagon receptor agonist developed by Boehringer Ingelheim and Zealand Pharma for obesity and MASH.

Weight Loss
Adipotide
Selective destruction of fat tissue blood vessels

A targeted chimeric peptide that triggers apoptosis in blood vessels supplying white adipose tissue, producing rapid fat loss in animal studies.

What to know about weight loss peptides

Weight loss peptides — particularly GLP-1 and dual GLP-1/GIP agonists — work by regulating appetite, slowing gastric emptying, and improving insulin sensitivity. They have become some of the most studied compounds in modern metabolic medicine. Each peptide in this category is profiled individually with its mechanism of action, typical dosing information, and known side-effect profile. Click any peptide to explore the full breakdown.

For research planning, pair this directory with our Dosage Calculator and Reconstitution Calculator.