Adipotide
A targeted chimeric peptide that triggers apoptosis in blood vessels supplying white adipose tissue, producing rapid fat loss in animal studies.
Overview
Adipotide is a chimeric peptide combining a fat-tissue-vasculature-targeting sequence with a pro-apoptotic sequence. It selectively triggers apoptosis of blood vessels supplying white adipose tissue, causing fat-tissue regression. Animal studies showed dramatic weight loss in obese primates without other toxicity, though human trials have been limited due to renal concerns.
Benefits
- Targets white adipose tissue specifically (spares muscle)
- Produces dramatic fat loss in primate studies
- Distinct mechanism from GLP-1 family
Mechanism of Action
An 'address-action' peptide — one end binds prohibitin on white adipose vasculature, the other end (a pro-apoptotic sequence) triggers apoptosis specifically in those blood vessels, depriving fat tissue of its blood supply.
Dosage (informational only)
- Typical range
- Research-only; human dosing not established
- Frequency
- Daily in animal studies
Human translation has been limited by renal toxicity concerns observed in trials.
Side Effects
- Renal toxicity has been the main concern
- Limited human safety data
- Theoretical impact on healthy vasculature
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