MOTS-c
A mitochondrial-derived peptide studied for metabolic regulation, insulin sensitivity, and exercise capacity.
Overview
MOTS-c is one of a class of newly discovered mitochondrial-derived peptides encoded within mitochondrial DNA. It signals to the nucleus to regulate metabolic homeostasis and has emerged as one of the most promising compounds in longevity and exercise research.
Benefits
- Improves insulin sensitivity
- Enhances mitochondrial energy production
- May boost endurance and exercise capacity
- Supports metabolic homeostasis
Mechanism of Action
Under metabolic stress, MOTS-c translocates from mitochondria to the nucleus and regulates AMPK signaling, glucose metabolism, and mitochondrial biogenesis-related gene expression.
Dosage (informational only)
- Typical range
- 5–10 mg per week (research dosing)
- Frequency
- 1–3x per week
Limited large-scale human data. Most evidence comes from animal and early human studies.
Side Effects
- Generally well-tolerated in studies
- Possible injection site reactions
- Long-term human safety not yet established
Related peptides
A synthetic tetrapeptide developed in Russia, studied extensively for telomerase activation and aging biomarkers.
A designer peptide that selectively triggers apoptosis in senescent cells, an emerging anti-aging strategy.
A nine-amino-acid neuropeptide first identified for its sleep-promoting effects, now studied for stress and circadian regulation.