Epithalon (Epitalon)
A synthetic tetrapeptide developed in Russia, studied extensively for telomerase activation and aging biomarkers.
Overview
Epithalon is a synthetic version of the natural pineal peptide epithalamin. Decades of Russian research suggest it may activate telomerase, regulate the pineal gland, and improve various aging biomarkers — making it one of the most popular peptides in the longevity community.
Benefits
- May activate telomerase enzyme
- Supports melatonin production
- Helps regulate circadian rhythm
- Studied for lifespan extension in animal models
Mechanism of Action
Believed to activate telomerase expression and modulate pineal gland function, with downstream effects on melatonin secretion and HPA axis regulation.
Dosage (informational only)
- Typical range
- 5–10 mg per day
- Frequency
- Short cycles of 10–20 days, 1–2x per year
Most evidence comes from Russian research. Large independent human trials are limited.
Side Effects
- Generally well-tolerated in available studies
- Possible injection site reactions
- Limited long-term human safety data
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