DSIP
A nine-amino-acid neuropeptide first identified for its sleep-promoting effects, now studied for stress and circadian regulation.
Overview
DSIP (Delta Sleep-Inducing Peptide) is a small neuropeptide originally discovered for its ability to induce slow-wave sleep. It's used in sleep, stress, and recovery protocols, though large-scale human clinical data remains limited.
Benefits
- May improve sleep quality and depth
- Modulates stress response
- Helps regulate HPA axis
- Generally well-tolerated in studies
Mechanism of Action
Modulates GABAergic and dopaminergic activity in the brain, with secondary effects on the HPA axis and circadian rhythm regulation.
Dosage (informational only)
- Typical range
- 100–300 mcg before bed
- Frequency
- Nightly during use cycles
Human evidence is limited. Most data comes from older studies and anecdotal use.
Side Effects
- Generally well-tolerated
- Possible vivid dreams
- Limited large-scale human trials
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