Humanin
A mitochondrial-derived peptide studied for cytoprotective effects, particularly in neurological and metabolic contexts.
Overview
Humanin is a 24-amino-acid peptide encoded within mitochondrial DNA — one of the founding members of the mitochondrial-derived peptide class alongside MOTS-c. It's been studied for protective effects in Alzheimer's models, cardiovascular disease, and metabolic dysfunction.
Benefits
- Protects against neurodegeneration in animal models
- Supports cellular survival under stress
- Studied for Alzheimer's-related applications
- May improve insulin sensitivity
Mechanism of Action
Binds multiple receptors including FPRL-1 and IL-6 family receptors, activating cytoprotective signaling and inhibiting Bax-mediated apoptosis pathways.
Dosage (informational only)
- Typical range
- Research dosing varies; human protocols not established
- Frequency
- Varies by study
Investigational. Most evidence comes from cell and animal studies.
Side Effects
- Limited human data
- Generally well-tolerated in available studies
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