Semax
A synthetic ACTH-derived peptide developed in Russia and widely studied for cognitive enhancement and stroke recovery.
Overview
Semax is a heptapeptide originally derived from a fragment of adrenocorticotropic hormone (ACTH). It has been studied extensively in Russia for cognitive impairment, stroke recovery, and neuroprotection, and has gained traction globally in nootropic and biohacking communities.
Benefits
- May improve memory, focus, and learning
- Increases brain-derived neurotrophic factor (BDNF)
- Studied for neuroprotection after ischemic events
- Modulates stress response without sedation
Mechanism of Action
Semax modulates the melanocortin system and elevates BDNF and NGF — key neurotrophic factors involved in synaptic plasticity, learning, and neuronal survival.
Dosage (informational only)
- Typical range
- 300–900 mcg per day (intranasal)
- Frequency
- Once or twice daily
Most commonly administered intranasally. Cycling is often used to maintain sensitivity.
Side Effects
- Generally well-tolerated
- Possible nasal irritation
- Mild restlessness in sensitive individuals
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