PEG-MGF
A pegylated form of mechano growth factor (MGF), a splice variant of IGF-1 that activates muscle satellite cells in response to mechanical loading.
Overview
MGF (mechano growth factor) is a splice variant of IGF-1 produced in muscle in response to mechanical stress. PEG-MGF is the pegylated synthetic version with extended half-life. It's used in research protocols targeting localized muscle hypertrophy and recovery, often timed around training sessions.
Benefits
- Activates muscle satellite cells
- Supports localized hypertrophy at injection site
- Promotes repair after muscle damage
- PEGylation extends half-life beyond native MGF
Mechanism of Action
Binds receptors on muscle satellite cells, triggering proliferation and fusion to existing muscle fibers — particularly in response to mechanical damage from training.
Dosage (informational only)
- Typical range
- 200–400 mcg per dose
- Frequency
- Post-workout, near target muscle
Often dosed locally for site-specific hypertrophy. Long-term human safety is poorly characterized.
Side Effects
- Possible mild hypoglycemia
- Injection site reactions
- Theoretical IGF-related concerns with chronic use
Related peptides
A GHRH analog designed for long-acting stimulation of natural growth hormone production.
A long-acting modified analog of insulin-like growth factor 1 with extended half-life and reduced binding-protein affinity.
A myostatin-binding protein studied for its potential to drive significant muscle hypertrophy by removing the body's natural growth ceiling.