Melanotan II (MT-2)
A synthetic melanocortin agonist studied for its effects on skin pigmentation and sexual function.
Overview
Melanotan II is a synthetic analog of alpha-melanocyte stimulating hormone (α-MSH). It is researched primarily for its tanning effects via melanin stimulation, and secondarily for its impact on libido through central melanocortin pathways.
Benefits
- Stimulates natural melanin production for tanning
- May enhance libido through MC4R activation
- Pigmentation effects achievable with limited UV exposure
Mechanism of Action
MT-2 activates the melanocortin receptors MC1R (driving melanogenesis in skin cells) and MC4R (modulating sexual response in the central nervous system), producing both pigmentation and libido effects.
Dosage (informational only)
- Typical range
- 0.25–1 mg per dose
- Frequency
- Loading phase daily, then maintenance 2–3x weekly
Not medically approved. Long-term safety is poorly characterized — particularly around new or changing moles. Dermatologic monitoring is strongly advised.
Side Effects
- Nausea, especially during loading
- Facial flushing and appetite suppression
- Darkening of existing moles or freckles
- Spontaneous erections in some users
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