GHK-Cu (Copper Peptide)
A naturally occurring copper-binding tripeptide widely studied in dermatology and increasingly popular in longevity protocols.
Overview
GHK-Cu is a small copper-binding peptide naturally present in human plasma at levels that decline with age. It has decades of dermatological research behind it and has become one of the fastest-growing peptides in skincare, hair restoration, and longevity-focused biohacking.
Benefits
- Stimulates collagen and elastin production
- Supports skin firmness and wound healing
- May promote hair follicle activity
- Antioxidant and anti-inflammatory effects
Mechanism of Action
GHK-Cu binds copper ions and acts as a signaling molecule that activates wound repair pathways, modulates gene expression toward a younger phenotype, and supports antioxidant defense systems in the skin.
Dosage (informational only)
- Typical range
- 1–3 mg subcutaneous; 2% topical concentration
- Frequency
- Daily (topical) or 2–3x weekly (subcutaneous)
Topical formulations are most common for cosmetic use. Subcutaneous protocols are more experimental.
Side Effects
- Generally well-tolerated topically
- Possible mild redness or irritation
- Rare allergic reactions
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