LL-37
A naturally occurring antimicrobial peptide of the cathelicidin family with broad-spectrum activity against bacteria, viruses, and fungi.
Overview
LL-37 is the only human cathelicidin and represents one of the body's primary innate immune peptides. It's studied for chronic infections (including biofilm-forming bacteria), wound healing, and immune modulation in conditions where microbial load drives inflammation.
Benefits
- Broad-spectrum antimicrobial action
- Active against biofilm-forming bacteria
- Supports wound healing
- Modulates host immune response
Mechanism of Action
Disrupts microbial membranes via electrostatic interaction with negatively charged lipids, while also modulating host inflammation through formyl peptide receptors.
Dosage (informational only)
- Typical range
- 100–1000 mcg per dose (research dosing varies widely)
- Frequency
- Protocols vary considerably
May trigger immune flares in chronically infected users. Large human safety data is limited.
Side Effects
- Possible immune flares from microbial die-off
- Injection site reactions
- Limited large-scale human safety data
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