Kisspeptin-10
A short peptide derived from kisspeptin, the master regulator of the reproductive hormone axis.
Overview
Kisspeptin-10 is the active C-terminal fragment of kisspeptin — the hypothalamic peptide that controls GnRH release and the entire reproductive endocrine cascade. It has gained traction in fertility research and as a potential alternative to HCG for stimulating natural testosterone production.
Benefits
- Stimulates LH, FSH, and downstream testosterone
- Supports natural fertility
- Engages physiologic HPG signaling
Mechanism of Action
Activates KISS1R receptors on hypothalamic GnRH neurons, triggering pulsatile GnRH release and the downstream LH/FSH/testosterone cascade.
Dosage (informational only)
- Typical range
- 50–200 mcg per dose
- Frequency
- Varies in research protocols
Long-term effects on HPG axis sensitivity remain under investigation.
Side Effects
- Generally well-tolerated in studies
- Possible injection site reactions
- Theoretical risk of axis desensitization with chronic use
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